Joan O Erebor,
Sylvester O Eraga
,
Matthew I Arhewoh,
Annastacia O Obi
For correspondence:- Sylvester Eraga Email: eragaso@uniben.edu Tel: +2348030884928
Published: 31 December 2015
Citation: Erebor JO, Eraga SO, Arhewoh MI, Obi AO. Comparative antimicrobial activity of Acalypha wilkesiana extracts and cream formulations. J Sci Pract Pharm 2015; 2(1):34-38 doi: 10.47227/jsppharm/v2i1.8
© 2015 The author(s).
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Purpose:This study was carried out to compare the antimicrobial activities of leaf extracts of Acalypha wilkesiana Muell Arg. (Euphorbiaceae) and cream formulations.
Methods:Extracts of Acalypha wilkesiana was obtained using four approaches; maceration of the powdered leaves with methanol, or water (hot and cold) and boiling the leaves and kept overnight before filtration. Agar diffusion method was used to determine the antimicrobial activity of the various extracts against test organisms and diameter of zones of inhibition measured. The extract with the best activity was formulated into creams and evaluated microbiologically against a commercial antimicrobial cream with plain creams acting as controls.
Results:The percentage yield of the extraction process was 1.7 % with methanol, 1.9 % with water, 4.04 % with boiled water and 2.72 % with the boiled and left overnight method. Diameter of zones of inhibition produced against gram-positive bacterium (Staphylococcus aureus), gram-negative bacteria (Escherichia coli andKlebsiella pneumoniae) and Candida albicans showed that the boiled aqueous extract was more potent in its antimicrobial activity. Pseudomonas aeruginosa was not inhibited by all the extracts.
Conclusion:The cream formulations of the superior extract was stable and had significant antibacterial and antifungal activity against the test pathogenic organisms.
