Sylvester O Eraga1
,
Penaere T Osahon2,
Bibiana O Mudiaga-Ojemu1,
Mascot O Ogbeide1,
Marvelous A Ojo1,
Magnus A Iwuagwu1
For correspondence:- Sylvester Eraga Email: eragaso@uniben.edu Tel: +2348030884928
Published: 28 December 2018
Citation: Eraga SO, Osahon PT, Mudiaga-Ojemu BO, Ogbeide MO, Ojo MA, Iwuagwu MA. In vitro interaction between artemether-lumefantrine and some antacids and edible clay. J Sci Pract Pharm 2018; 5(1):206-208 doi: 10.47227/jsppharm.v5i1.08
© 2018 The author(s).
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Purpose: The study investigated the in vitro interactions between artemether-lumefantrine and some antacids and edible clay. Methods: Adsorption studies using three antacids; magnesium trisilicate (MT), aluminium hydroxide (AH), magnesium hydroxide (MH) as well as edible clay (EC) were carried out. A tablet brand was evaluated for tablet properties and used to determine the effects of the adsorbents on tablet disintegration time and dissolution. Results: Adsorption followed the rank order; MT(79.98%) > MH(74.21%) > AH(70.90%) > EC(37.10%) and AH(99.90%) > MH(76.20%) > MT(73.21%) > EC(47.11%) for artemether and lumefantrine respectively. The adsorbents had no effect on tablets disintegration times. There was retardation of drug dissolution and the order was: Emtrisil®(49.58%) > MT(52.20%) > MH(58.92%) > AH(62.67%) > EC(67.42%) and Emtrisil®(59.50%) > AH(62.76%) > MH(70.20%) > MT(72.80%) > EC(80.92%) as against 93.80% as against 93.86% in 0.1N HCl for artemether and lumefantrine respectively. Conclusion: The co-administration of these antacids with artemether/lumefantrine tablets should be strongly discouraged.
