Original Research Article | OPEN ACCESS
Drug related problems and implications for pharmaceutical care interventions in hypertensive outpatients in a Nigerian hospital

Aliyu Samaila , Aminu A. Biambo, Nuruddeen Usman, Hussaina H. Aliyu

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto;

For correspondence:-  Aliyu Samaila   Email: rxmusawa88@gmail.com   Tel:+2348034608419

Published: 29 December 2018

Citation: Samaila A, Biambo AA, Usman N, Aliyu HH. Drug related problems and implications for pharmaceutical care interventions in hypertensive outpatients in a Nigerian hospital. J Sci Pract Pharm 2018; 5(2):281-286 doi:

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..


PURPOSE: To study drug related problems (DRPs) among hypertensive patients, pattern of antihypertensive drugs used and percentage of patients that achieved JNC 8 target goal BP in a Nigerian hospital.

METHODS: This was a prospective cross-sectional study over a period of three months. A total of 109 eligible hypertensive patients were consecutively sampled. Data was collected from the patients’ folders and direct interviews using a data collection form. Compliance to medication was assessed using the four (4) items patients’ report Morisky compliance score indicator. .

RESULTS: A total of 171 DRPs were identified and effect of drug treatment not optimal was the highest (71.6%) DRP encountered. The mean systolic and diastolic blood pressures (SBP and DBP) were found to be 150 ± 27.71 and 92 ± 16.29 mmHg respectively, and only 26.6% of the patients achieved JNC 8 target goal blood pressure (BP). Number of drug related problems and adherence score correlated positively and significantly with SBP at P≤0.01.

CONCLUSION: A total of 171 DRPs were identified which could partly be associated with majority of the patients not achieving their target goal BP. This has justified the introduction of pharmaceutical care interventions to hypertensive outpatients receiving care in the hospital.


Keywords: hypertension, drug treatment, target goal BP

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