Original Research Article | OPEN ACCESS
Investigation into the use of acid modified millet (Pennisetum glaucum) starch mucilage as tablet binder

Ogochukwu A Meko1 , Bibiana O Mudiaga-Ojemu2, Chiagoziem P Ubah2, Sylvester O Eraga2, Magnus A Iwuagwu2

1Department of Pharmaceutics, Faculty of Pharmacy, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria.; 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria..

For correspondence:-  Ogochukwu Meko   Email: adamekoh@gmail.com   Tel:+23407038611554

Published: 29 December 2018

Citation: Meko OA, Mudiaga-Ojemu BO, Ubah CP, Eraga SO, Iwuagwu MA. Investigation into the use of acid modified millet (Pennisetum glaucum) starch mucilage as tablet binder. J Sci Pract Pharm 2018; 5(2):267-274 doi:

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the binding properties of the modified (acid treated) millet (Pennisetum glaucum) starch mucilage in comparison with maize starch BP on some physical characteristics of paracetamol tablets.

Method: Pennisetum glaucumstarch was extracted and subjected to acid modification. Mucilages of the modified starch and maize starch BP was used to prepare paracetamol granules and tablets by wet granulation method at various concentrations. The granules were characterized for their flow properties while the tablets were characterized for their tablet parameters. In vitro drug release and FTIR compatibility studies was carried out on the tablet formulation.

Result: The starch extraction and modification processes gave a percentage yield of 53.65 and 58.74 % respectively. Prepared granules were free flowing with Carr’s indices, Hausner’s ratios and angles of repose of ≤15%, ≤1.2 and <31°, respectively. At all binder concentrations, the tablets showed satisfactory hardness(5.15-7.75 kp), friability values (< 1.0 %) and disintegration times(<15 min).The dissolution studies showed that all batches achieved over 70 % drug release in 30 min while the compatibility study revealed no interaction between paracetamol and the modified starch.

Conclusion: The results from the study shows that modified millet starch when used as a binder in paracetamol tablets exhibited comparable granule and tablet properties with maize starch BP.

 

 

 

 

Keywords: Pennisetum glaucum, modification, starch, binder, paracetamol tablets


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