Original Research Article | OPEN ACCESS

Investigation of the disintegration behaviour of paracetamol and metronidazole tablets in different beverages

Sylvester O Eraga , Matthew I Arhewoh, Odera C Unachukwu, Magnus A Iwuagwu

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria;

For correspondence:-  Sylvester Eraga   Email:  eragaso@uniben.edu   Tel:  +2348030884928

Published: 31 December 2015

Citation: Eraga SO, Arhewoh MI, Unachukwu OC, Iwuagwu MA. Investigation of the disintegration behaviour of paracetamol and metronidazole tablets in different beverages. J Sci Pract Pharm 2015; 2(1):23-27 doi: 10.47227/jsppharm.v2i1.6

© 2015 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (CC BY-NC 4.0 - http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction (non-commercially) in any medium, provided the original work is properly credited..

Abstract

Purpose: To assess how different beverage media impact the disintegration times of some commonly used solid oral dosage formulations namely, paracetamol and metronidazole uncoated tablets.
Methods: Ten different types of media comprising non-alcoholic beverages (orange juice, sparkling fruit juice, cola and lemon/lime soft drinks), alcoholic beverages of 5, 11 and 18 %v/v alcohol, malt drink and 0.1 N hydrochloric acid were compared with distilled water at 37 ± 1 °C in their disintegration times of paracetamol and metronidazole tablets.
Results: Disintegration time of paracetamol tablets was significantly retarded by the beverages with times ranging from 4.4 - 8.6 min as against 3.5 min in distilled water. Orange juice gave the highest retardation while the malt drink facilitated disintegration with times of 8.6 and 2.8 min respectively. Metronidazole tablets disintegration time was not significantly retarded by the beverages against a time of 1.1 min in distilled water except orange juice with a disintegration time of 4.2 min.
Conclusion: Although the effect on the disintegration times of the tablets by the different beverages did not result in times above compendial requirement of 15 min, care should be taken when replacing water with any beverage in ingesting tablet drug products especially those that are slow in disintegration.

Keywords: Disintegration, beverages, retardation, paracetamol, metronidazole

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