Florence E Eichie
,
Florence I Iweka,
Ayo E Abel,
Omoye E Cash-Torunarigha
For correspondence:- Florence Eichie Email: eichiefe@yahoo.com Tel: +234-8036347181
Published: 31 December 2015
Citation: Eichie FE, Iweka FI, Abel AE, Cash-Torunarigha OE. Physicochemical evaluation of chrysophyllum abidum (sapotacae) gum extract and its tableting characteristics in comparison with acacia Senegal gum. J Sci Pract Pharm 2015; 2(1):28-33 doi: 10.47227/jsppharm.v2i1.7
© 2015 The author(s).
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Purpose: A comparative study was carried out to investigate the physicochemical and tableting characteristics of the gum extract fromChrysophyllum abidum and Accacia Senegal on paracetamol granules.
Methods: Chrysophyllum abidum gum was precipitated with methanol and the physicochemical properties (swelling index, particle density, and solubility in various solvents) were evaluated and compared with acacia gum as standard. Varying concentrations (0 – 7.5%w/v) of either Chrysophyllum abidum or Acacia senegal mucilages were used to wet 15 g each of paracetamol powder as a poorly compressible drug model to form granules. Resulting granules were compressed to tablets (500±9.5 mg) at a constant load of 35 arbitrary units on the scale. The tablets were equilibrated over night for 24 hours before their evaluations. Tablet properties assessed included packing fraction, friability, and tensile strength.
Results: C.albidum gum displayed similar physicochemical properties in colouration and solubility in both aqueous and organic solvents as well. Both gums were soluble in aqueous solvent only. The viscosities of mucilages from the gums showed that C. albidum was five times more viscous than A. Senegal, and viscosity was concentration dependent. C. albidum formed compacts which were comparable with A. Senegal at the arbitrary load employed. The packing fraction ofC.abidum was in the range of 0.71 – 0.8 while A. senegal ranged from 0.85 – 0.87. This showed that A. Senegal formed more consolidated tablets with closer packing of the granules than C. albidum. Tablet formed fromC. albidum were more friable with values ranging from (1.0 - 2.7%) than those from A.senegal (0.7 – 1.5%). Tensile strength values ranged from 0.37 – 0.71 MNm-2 (C .albidum) and 0.46 – 0.81MNm-2 for(A. Senega) respectively.
Conclusion: The results from the study showed that the physicochemical and tableting characteristics of C.albidumcompared favourably with A. Senegal. The novel gum extracted from C.albidum could therefore serve as a substitute binder in tablet formulations.
