Original Research Article | OPEN ACCESS

Preliminary endocrinological, histological and haematological investigation of Alchornea laxiflora (Euphorbiaceae) leaf extract effects on the ovary, uterus and cervix of mouse models

Enitome E Bafor1 , Stacy E Eyohan1, Osemelomen Omoruyi1, Uloma B Elvis-Offiah2, Buniyamin Ayinde3, Gerald I Eze4, Isibhakhomhen V Okosun1, Philip A Obarisiagbon1, Osamwonyi Igbinuwen5, Kadiri P Braimoh6

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Nigeria; 2Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Nigeria; 3Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, Nigeria; 4Department of Anatomy, School of Basic Medical Sciences, University of Benin, Nigeria; 5Haematology Department, University of Benin Teaching Hospital, Benin City, Nigeria; 6Histopathology Department, University of Benin Teaching Hospital, Benin City, Nigeria Nigeria.

For correspondence:-  Enitome Bafor   Email:  enitome.bafor@uniben.edu

Published: 31 December 2015

Citation: Bafor EE, Eyohan SE, Omoruyi O, Elvis-Offiah UB, Ayinde B, Eze GI, et al. Preliminary endocrinological, histological and haematological investigation of Alchornea laxiflora (Euphorbiaceae) leaf extract effects on the ovary, uterus and cervix of mouse models. J Sci Pract Pharm 2015; 2(1):55-63 doi: 10.47227/jsppharm.v2i1.12

© 2015 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (CC BY-NC 4.0 - http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction (non-commercially) in any medium, provided the original work is properly credited..

Abstract

Purpose: The decoction from the leaves of Alchornealaxiflora (AL) is often used by women in Edo state, Nigeria to prevent preterm birth (miscarriage). This study was therefore undertaken to investigate the effect of the extract on the female reproductive structures.
Methods: The methanol leaf extract of AL (100 mg/kg and 1000 mg/kg p.o.) was administered for  6 days at 10 a.m. daily to non-pregnant female mice using 0.2 ml of 10 % tween 80 as negative control and progesterone (10 mg/kg s.c.) as positive control. The weights of the animals were taken before administration, daily during administration and after AL administration.
Results: The findings reveal that the lower dose of AL (100 mg/kg) showed progesterone-like effects on the ovaries, uterus and cervical glands causing increased number and development of ovarian follicles and proliferation of the uterine endometrial glands while the high dose resulted in extrusion of the ovum from the Graafian follicle and resulted in glandular hyperplasia and atrophy of the uterine stroma.
Conclusion: AL has been shown to exert progesterone-like effects at low dose and this may account for its use by traditional healers in Nigeria for maintaining pregnancy.

Keywords: miscarriage, preterm birth, progesterone, mice

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