Original Research Article | OPEN ACCESS

In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations

Chukwuemeka P Azubuike , Cynthia A Uzoeto, Nwamaka H Igbokwe, Cecilia I Igwilo

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, College of Medicine Campus, PMB 12003, Surulere, Lagos, Nigeria;

For correspondence:-  Chukwuemeka Azubuike   Email:  cazubuike@unilag.edu.ng   Tel:  +2348033618556

Published: 31 December 2016

Citation: Azubuike CP, Uzoeto CA, Igbokwe NH, Igwilo CI. In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations. J Sci Pract Pharm 2016; 3(1):135-144 doi: https://doi.org/10.47227/jsppharm/v3i1.9

© 2016 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Seeds of Sorghum bicolor (SB) and leaves of Mangifera indica (MI) are used in ethnomedicine in the management of sickle cell disorder (SCD). The present study involves phytochemical analysis of the methanolic extracts of the plant parts and evaluation of their antibacterial, antioxidant and antisickling potentials as well as syrups containing the extracts.
Methods: Phytochemical analysis of the methanolic extracts were evaluated using standard methods while the functional groups were elucidated using Fourier transform infrared spectroscopy (FT-IR). Antioxidant properties were determined by comparing their radical scavenging activity against gallic acid and ascorbic acid while antibacterial properties of the plant extracts were evaluated against Salmonella typhi, Pseudomonas aeruginosa, Escherichia coli and Staphylococus auerus. The syrups containing the extracts were evaluated and compared to Ciklavit:8;.
Results: Phytochemical screening and FI-TR spectra revealed the presence of bioactive molecules including flavonoids and phenols. The two extracts had comparable antioxidant properties however, only Mangifera indica extract had antibacterial activity against tested organisms. Both extracts including their syrup formulation had antisickling activity with the syrup containing 500 mg SB and 250 mg MI having superior activity.
Conclusion: Sorghum bicolor seeds and Mangifera indica leaves extracts and their formulations might play a great role in the management of SCD

Keywords: Antisickling; antioxidant; antimicrobial; Mangifera indica; Sorghum bicolor

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