Collins O Airemwen
Michael U Uhumwangho,
Gift E Ofolo
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria;
For correspondence:- Collins Airemwen
Tel: +234 8133737933
Published: 31 December 2017
Airemwen CO, Uhumwangho MU, Ofolo GE.
Formulation of sustained release matrix tablets of metronidazole using sintering technique. J Sci Pract Pharm 2017; 4(1):152-160
© 2017 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: The study was conducted to formulate and evaluate controlled release metronidazole matrix tablets by thermal sintering using Irvingia gabonesis (IG) gum as binder.
Methods: Metronidazole granules were prepared by wet granulation technique using 10 %w/w each of the extracted IG and tragacanth gums and the prepared granules were evaluated for micromeritic properties. The granules were compressed into tablets and some of the prepared tablets were subjected to thermal sintering at 50 and 60 ºC for 1, 3 and 5 h. Both the sintered and unsintered tablets were evaluated for physicotechnical properties.
Results: The results revealed that the prepared metronidazole granules were free flowing with angles of repose of ≤ 28º and Carr’s indices ≤ 15 %. An increase in tablet hardness occurred with increase in sintering temperature and time while the percentage friability decreased. The in-vitro dissolution profile of the prepared controlled release matrix tablet of metronidazole showed that the optimum drug retardation occurred in tablets sintered at 60 ºC for 5 h.
Conclusion: The study has revealed that IG gum at a concentration of 10%w/w possesses good binding properties and can be utilized in the formulation of controlled release matrix tablets of metronidazole by thermal sintering.
Thermal sintering, Irvingia gabonesis, matrix tablets, metronidazole