Original Research Article | OPEN ACCESS

Antinociceptive Effect of Methanol Extracts of Parquentina nigrescens (afzel) bullock (Periplocaceae) Fruit Bark

Lucky O Okunrobo , John O Uwaya, Precious E Ehimhen,

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, university of Benin, Benin City. Nigeria;

For correspondence:-  Lucky Okunrobo   Email:  okunrobo@uniben.edu   Tel:  +234-8034725416

Published: 30 December 2014

Citation: Okunrobo LO, Uwaya JO, Ehimhen PE, Antinociceptive Effect of Methanol Extracts of Parquentina nigrescens (afzel) bullock (Periplocaceae) Fruit Bark. J Sci Pract Pharm 2014; 1(1):16-19 doi: https://doi.org/10.47227/jsppharm/v1i1.4

© 2014 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose:To investigate the antinociceptive activity of the methanol fruit bark extract of Parquetina nigrescens.
Methods:The methanol fruit bark extract of Parquetina nigrescens was screened for antinociceptive activity using formalin and acetic acid-induced pain method at doses 50mg/kg, 100mg/kg and 200mg/kg in Swiss albino mice.
Results:The results obtained shows significant (p< 0.05 and p< 0.01) dose dependent antinociceptive activity of the extract of the fruit bark.
Conclusion:The study has demonstrated that the methanol extract of fruit bark of Parquetina nigrescens exerts potential dose-dependent analgesic effect in animal models both centrally and peripherally

Keywords: Parquentina nigrescens, fruit bark, antinociceptive action, formalin induced pain.

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