Lucky O Okunrobo
,
John O Uwaya,
Precious E Ehimhen,
For correspondence:- Lucky Okunrobo Email: okunrobo@uniben.edu Tel: +234-8034725416
Published: 30 December 2014
Citation: Okunrobo LO, Uwaya JO, Ehimhen PE, Antinociceptive Effect of Methanol Extracts of Parquentina nigrescens (afzel) bullock (Periplocaceae) Fruit Bark. J Sci Pract Pharm 2014; 1(1):16-19 doi: 10.47227/jsppharm.v1i1.4
© 2014 The author(s).
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Purpose:To investigate the antinociceptive activity of the methanol fruit bark extract of Parquetina nigrescens.
Methods:The methanol fruit bark extract of Parquetina nigrescens was screened for antinociceptive activity using formalin and acetic acid-induced pain method at doses 50mg/kg, 100mg/kg and 200mg/kg in Swiss albino mice.
Results:The results obtained shows significant (p< 0.05 and p< 0.01) dose dependent antinociceptive activity of the extract of the fruit bark.
Conclusion:The study has demonstrated that the methanol extract of fruit bark of Parquetina nigrescens exerts potential dose-dependent analgesic effect in animal models both centrally and peripherally
