Fabian C Amaechina1
Adaeze P Uchendu1,
Cordelia I Oboh2,
Nnamdi I Agokei3,
Chukwueniwe J Eboka3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy;
2Department of Science Laboratory Technology;
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, University of Benin, PMB 1154, Benin City, 300001, Nigeria.
For correspondence:- Fabian Amaechina
Published: 31 December 2017
Amaechina FC, Uchendu AP, Oboh CI, Agokei NI, Eboka CJ.
Preliminary comparative effect of the aqueous extract of Persea americana seeds on the blood pressure of normotensive rabbits and rats. J Sci Pract Pharm 2017; 4(1):177-181
© 2017 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: Different parts of Persea americana are widely used in ethno-medicine to treat and manage various ailments such as epilepsy, febrile convulsion and hypertension. The aim of this study was to comparatively evaluate the blood pressure lowering effect of aqueous seed extract of Persea americana on rabbits and rats at different graded doses and to assess the influence of species variation on dosage tolerance.
Methods: The animals were prepared for blood pressure evaluation following well established protocol. Comparatively, blood pressure evaluation was carried out in normotensive rabbits and rats, at the dose range of 0.625-5.0 mg/kg and 0.625-2.5 mg respectively.
Results: The extract caused a dose dependent (0.625 - 5.0 mg/kg) fall in the systolic, diastolic and mean arterial pressure in both rabbits and rats blood pressure. The extract significantly reduced the mean arterial blood pressure from the basal level of 112.5 ± 9.35 to 69.86 ± 10.15 mmHg at the dose of 5.0 mg/kg in the rabbits and from the basal of 95.65 ± 10.33 mmHg means arterial pressure to 43.1 ± 11.15 mmHg in the rats at the dose of 2.5 mg/kg (p < 0.01).
Conclusion: The results of the study showed that extract of Persea americana has blood pressure lowering effect in the rodent species evaluated, possibly with a narrow therapeutic margin
Persea americana, normotensive, rat, rabbit, effective dose