Fabian C Amaechina1
,
Adaeze P Uchendu1,
Cordelia I Oboh2,
Nnamdi I Agokei3,
Chukwueniwe J Eboka3
For correspondence:- Fabian Amaechina Email: amaefabs@uniben.edu Tel: +2348023303138
Published: 31 December 2017
Citation: Amaechina FC, Uchendu AP, Oboh CI, Agokei NI, Eboka CJ. Preliminary comparative effect of the aqueous extract of Persea americana seeds on the blood pressure of normotensive rabbits and rats. J Sci Pract Pharm 2017; 4(1):177-181 doi: 10.47227/jsppharm.v4i1.5
© 2017 The author(s).
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Purpose: Different parts of Persea americana are widely used in ethno-medicine to treat and manage various ailments such as epilepsy, febrile convulsion and hypertension. The aim of this study was to comparatively evaluate the blood pressure lowering effect of aqueous seed extract of Persea americana on rabbits and rats at different graded doses and to assess the influence of species variation on dosage tolerance.
Methods: The animals were prepared for blood pressure evaluation following well established protocol. Comparatively, blood pressure evaluation was carried out in normotensive rabbits and rats, at the dose range of 0.625-5.0 mg/kg and 0.625-2.5 mg respectively.
Results: The extract caused a dose dependent (0.625 - 5.0 mg/kg) fall in the systolic, diastolic and mean arterial pressure in both rabbits and rats blood pressure. The extract significantly reduced the mean arterial blood pressure from the basal level of 112.5 ± 9.35 to 69.86 ± 10.15 mmHg at the dose of 5.0 mg/kg in the rabbits and from the basal of 95.65 ± 10.33 mmHg means arterial pressure to 43.1 ± 11.15 mmHg in the rats at the dose of 2.5 mg/kg (p < 0.01).
Conclusion: The results of the study showed that extract of Persea americana has blood pressure lowering effect in the rodent species evaluated, possibly with a narrow therapeutic margin
