Emeka D Odai1
,
Ozoemene N Obuekwe2,
Raymond I Ozolua1
For correspondence:- Emeka Odai Email: danielson.odai@uniben.edu Tel: +2348091749166
Published: 28 December 2018
Citation: Odai ED, Obuekwe ON, Ozolua RI. Cardiorespiratory changes following injection of local anesthetics with different concentrations of adrenaline during simple tooth extraction: Preliminary report of a prospective clinical trial. J Sci Pract Pharm 2018; 5(1):203-205 doi: 10.47227/jsppharm.v5i1.07
© 2018 The author(s).
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Purpose: To evaluate some of the cardio-respiratory effects of the commonly used LAAs in dental patients. Methods: This was prospective clinical trial. Patients were divided randomly into 4 cohorts: L-200 cohort, L-100 cohort, A-200 cohort and A-100 cohort. There were 25 patients in L-200, L-100 cohort and A-200 cohorts each, while A-100 cohort had 26 patients. L-200 cohort was given 1.8 mls of lidocaine 2% with adrenaline 1:200,000. L-100 cohort was given 1.8 mls of 2% lidocaine with adrenaline 1:100,000, A-200 cohort was given 1.8 mls of articaine 4% with adrenaline 1:200,000. A-100 cohort was given 1.8 mls of articaine 4% with adrenaline 1:100,000. One hundred and one patients were included in the study. There were 60 (59.4%) females and 41 (40.6%) males. Results: Mean respiratory rate decreased following the injection of the LAAs: A-100, A-200, L-100 and L-200 to the respective cohorts, and maintained a steady decrease throughout the study period; T0 through T3. The heart rate, systolic blood pressure and diastolic blood pressure increased following injection of LAAs being investigated but no statistically significant increase was noted. Conclusion: The A-200 cohort, was a source of the statistically significantly low oxygen concentrations, with mean (SD) of 91.2 (11.4) % (P=0.000) at T0 and 92.8 (11.4) % (P=0.001) at T1.
