Proceeding | OPEN ACCESS
In vitro uterine activity of extract and fractions of Manniophyton fulvum Mull. Arg (Euphorbiaceae) in mice

Josephine O Ofeimun1 , Chidi U Okafor1, Enitome E Bafor2, Fabian C Ameachina2, Buniyamin A Ayinde1

1Department of 1Pharmacognosy, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria.; 2Department of Pharmacology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria..

For correspondence:-  Josephine Ofeimun   Email: jofeimun@uniben.edu   Tel:+2348064942568

Published: 28 December 2018

Citation: Ofeimun JO, Okafor CU, Bafor EE, Ameachina FC, Ayinde BA. In vitro uterine activity of extract and fractions of Manniophyton fulvum Mull. Arg (Euphorbiaceae) in mice. J Sci Pract Pharm 2018; 5(1):218-219 doi:

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Manniophyton fulvum is a plant in the Euphorbiacaea family that is used to manage dysmenorrhea amongst other conditions. It was investigated for its effect on the isolated mice uterus.

Methods: Methanol extract (ME) of the leaves was partitioned into chloroform (CF) and aqueous fractions (AF) and their effects on amplitude and frequency of uterine contractions were evaluated.

Results: The methanol extract and aqueous fraction were observed to significantly (p<0.05 and 0.01) increase the frequency and amplitude of contraction of the smooth muscle of the uterus in a concentration-dependent manner in the presence and absence of an agonist, while the chloroform fraction decreased the frequency and amplitude of contraction (p<0.05) in a concentration-dependent manner. The presence of saponins, alkaloids, tannins, flavonoids and anthraquinones were detected in the plant material.

Conclusion: This work provides scientific evidence for the use of the plant to manage dysmenorrhea and similar conditions in ethnomedicine and this may form the basis for further investigation of the plant.

 

 

Keywords: Manniophyton fulvum, in vitro, uterine, Euphorbiaceae, dysmenorrhea


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