Cyprian O Uzochukwu
,
Florence E Eichie
For correspondence:- Cyprian Uzochukwu Email: ositadinma01@yahoo.com Tel: +2348037777490
Published: 28 December 2018
Citation: Uzochukwu CO, Eichie FE. Physicochemical characterization of Sus Scrofa Domesticus fat and release profiles of ibuprofen matrix granules formulated from it. J Sci Pract Pharm 2018; 5(1):220-221 doi: 10.47227/jsppharm.v5i1.14
© 2018 The author(s).
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Purpose: To investigate the physicochemical characteristics and drug release profiles of Sus Scrofa Domesticus (SSD) fat and its potential application as matrix former in formulation of ibuprofen granules. Methods: Sus Scrofa Domesticus fat was obtained from domestic edible pig and extracted by boiling with water. Organoleptic and physicochemical tests were carried out. Batches of Ibuprofen granules were prepared by melt granulation using varying concentrations of the extracted SSD fats and carnauba wax as standard matrix former while conventional granules were formed with maize starch as binder for control. Resulting granules were evaluated for flow property, bulk and tap densities and encapsulated in hard gelatin capsules and in vitro drug release studies was carried out. Results: The physicochemical properties of the SSD fat were within acceptable limits. Granules formulated with SSD fat exhibited poor flow properties with angle of repose ≥ 36°, and Carr’s index ≥ 29%, while granules formulated with the standard carnauba wax were free flowing with angle of repose ≤ 31° and Carr’s index ≤ 19%. Dissolution profiles for conventional granules showed a maximum drug release of 98% in 1 h for SSD fat at concentration of 2.5 %w/w and 90% for carnauba wax at the same concentration. Conclusion: Formulation of ibuprofen granules by melt granulation modified the drug release profiles by the SSD and carnauba waxes.
