Rose O Imade
,
Buniyamin A Ayinde
For correspondence:- Rose Imade Email: rozy4god@gmail.com Tel: +2348032444024
Published: 28 December 2018
Citation: Imade RO, Ayinde BA. Comparative cytotoxic and growth inhibitory effects of the volatile oils of Hyptis suaveolens, Ocimum basilicum and Ocimum gratissimum leaves. J Sci Pract Pharm 2018; 5(1):222-224 doi: 10.47227/jsppharm.v5i1.15
© 2018 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). This license requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only. .
Purpose: To determine the growth inhibitory and cytotoxic effect of volatile oils obtained from Hyptis suaveolens, Ocimum basilicum and Ocimum gratissimum leaves. Methods: The VOs obtained from the three plants were examined for cytotoxicity (10 - 40 µg/mL) on tadpoles of Ranniceps ranninus and antiproliferative effects (1 – 30 mg/mL) using Sorghum bicolor seeds. Results: All the VOs produced 100 % mortality on the tadpoles at 40 µg/mL. Concentration-dependent growth inhibition was observed with all the oils. Conclusion: VOs of Hyptis suaveolens, Ocimum. basilicum and Ocimum gratissimum have cytotoxic and antiproliferative effects on rapidly growing cells as found in tumour-related ailments.
