Henry O Uwumarongie1
,
Doris N Onwukaeme1,
Ighodaro Igbe2
For correspondence:- Henry Uwumarongie Email: osamuyi.uwumarongie@uniben.edu Tel: +2348036700935
Published: 28 December 2018
Citation: Uwumarongie HO, Onwukaeme DN, Igbe I. GC-MS metabolite profiling, antinociceptive and antipyretic activities of methanol stem bark extract of Tabernaemontana pachysiphon Stapf. (Apocynaceae). J Sci Pract Pharm 2018; 5(1):228-230 doi: 10.47227/jsppharm.v5i1.17
© 2018 The author(s).
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Purpose: The study was designed to determine the GC-MS metabolite profile and evaluate the antinociceptive and antipyretic activities of the methanol stem bark extract of Tabernaemontana pachysiphon. Methods: Metabolite profile was assessed using GC-MS technique while the antinociceptive and antipyretic activities were evaluated using the acetic acid induced writhes, hot plate and baker’s yeast induced pyrexia models. Results: GC-MS profiling revealed the presence of forty metabolites in the extract, with n – Hexadecanoic acid (27.49%), Oleic acid (14.60%) and Octadecanoic acid (6.38%) being the most predominant metabolites. In the acetic acid induced writhes, hot plate and baker’s yeast induced pyrexia models; the extract exhibited a dose – dependent activity that was comparable to the reference drugs (Acetylsalicylic acid, pentazocine and paracetamol). Conclusion: The methanol extract of T. pachysiphon possess useful metabolites, antinociceptive and antipyretic activities.
