Sylvester O Eraga
,
Cynthia O Damisah,
Michael U Uhumwangho,
Magnus A Iwuagwu,
For correspondence:- Sylvester Eraga Email: eragaso@uniben.edu Tel: +2348030884928
Published: 30 December 2014
Citation: Eraga SO, Damisah CO, Uhumwangho MU, Iwuagwu MA, Development and Evaluation of Novel, Multifunctional Co-Processed Excipients for Direct Compression of Paracetamol Tablets. J Sci Pract Pharm 2014; 1(1):25-30 doi: 10.47227/jsppharm.v1i1.6
© 2014 The author(s).
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Purpose:To develop a novel multifunctional pharmaceutical excipient for direct compression (DC) of paracetamol.
Methods:The novel excipient was prepared by co-processing gelatinized maize starch with sodium carboxyl methyl cellulose and microcrystalline cellulose in a ratio of 2:1:1, dried and pulverized into powder. DC was applied in preparing different batches of paracetamol tables with drug-excipient ratios of 1:1, 1:2, 1:3, and 1:4. Both the excipient powder, the blended mixture of paracetamol and the excipient powder and the tablets formulated were evaluated for their physicochemical properties including bulk, tapped and particle densities, Hausner’s ratio, Carr’s index, angle of repose, flow rate, moisture content, swelling index and hydration capacity while the tablets formulated were evaluated for uniformity of weight, dimensions, hardness, friability, disintegration time, moisture sorption and dissolution rate.
Results:The co-processed novel excipient exhibited excellent flow properties (angle of repose; 25º) with a high moisture content (9 %), good swelling index (15.10) and hydration capacity (5.26). The powder mix also showed good flow properties that were proportional to the concentration of the excipient. Formulated tablets were of good quality with regard to weight, hardness, drug content and disintegration time except friability where two batches failed the official specification.
Conclusion:The co-processed excipient developed in this study was found to be a promising directly compressible vehicle for the preparation of compressed tablets for poorly compressible drugs
