Original Research Article | OPEN ACCESS

Assessment of the binding properties of methyl starch obtained from Ipomoea batatas in paracetamol tablet formulations

Mohammed Achor1 , Shadrack J Madu2

1Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Sokoto State, Nigeria.; 2Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria..

For correspondence:-  Mohammed Achor   Email:  munchors001@yahoo.com   Tel:  +234-8035998458

Published: 20 December 2020

Citation: Achor M, Madu SJ. Assessment of the binding properties of methyl starch obtained from Ipomoea batatas in paracetamol tablet formulations. J Sci Pract Pharm 2020; 7(1):355-364 doi: https://doi.org/10.47227/jsppharm.v7i1.2

© 2020 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The study assessed the binding property of methyl starch obtained from Ipomoea batatas starch compared to maize starch BP (MS).

Methods: Ipomoea batatas starch (IBS) was extracted and reacted with dimethyl sulphate to obtain methyl starch (IMS). The physicochemical and micromeritic properties of the starches were determined using standard methods prior to formulation of paracetamol tablets with the starches and maize starch BP as binder. The formulated tablets were assessed for their weight variation, crushing strength, friability, disintegration and drug release profile.

Results: The degree of substitution of IMS produced was 0.6 and the reaction efficiency was 20%. The swelling and hydration capacities of IMS and IBS were 34.52, 14.38% and 1.66, 1.88%, respectively. The micromeritic parameters; bulk density (0.53 g/mL), tapped density (0.55 g/mL), Carr’s index (3.64%), Hausner’s ratio (1.04), true density (2.11 g/mL) and powder porosity (2.30) of IMS were superior to those of IBS. The crushing strength and friabilityof the paracetamol tablets formulated with IMS were mechanically stronger than those of IBS and MS. Drug release from tablets formulated with IMS was however lower than those of IBS and MS.

Conclusion: The result of quality assessment of the tablets produced established IMS as suitable binder in comparison to IBS and MS in the formulation of paracetamol tablets in view of its improved crushing strength and reduced friability.

 

 

Keywords: Methyl starch, binder, tablet formulation, Ipomoea batatas

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