Original Research Article | OPEN ACCESS

The effect of quality of life, medication adherence and number of medications on patients with epilepsy

Wednesday J Edefo1 , Penaere T Osahon2

1Department of Pharmacy, Federal Neuropsychiatric Hospital, PMB 1108, Benin City, 300001, Nigeria.; 2Departments of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria..

For correspondence:-  Wednesday Edefo   Email:  edefojoshua2000@yahoo.com   Tel:  +2347035800341

Published: 20 December 2020

Citation: Edefo WJ, Osahon PT. The effect of quality of life, medication adherence and number of medications on patients with epilepsy. J Sci Pract Pharm 2020; 7(1):376-382 doi: https://doi.org/10.47227/jsppharm.v7i1.4

© 2020 The author(s).
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: In the management of people with epilepsy the effect of variables such as of quality of life, medication adherence, and number of antiepileptic drugs on seizure control are veritable tools to optimize their care thus the study aimed to assess the correlation and relationship of quality of life, medication adherence, and number of medications on seizure control.

Methods:  This was a cross-sectional study of sample size of 141 respondents using systematic sampling techniques. Frequency of seizures was gotten from self-developed proforma. Adherence was evaluated using the Modified Morisky Adherence Scale (MMAS) instrument while Quality of life was evaluated using Quality of Life in Epilepsy Patient Weighted-10 questionnaire (QOLIE-10P) instrument. Correlation analysis was used to determine if these variables were related while multiple regression analysis was done to determine the extent these variables were related.

Results: Seizure control and quality of life, seizure control and medication adherence, and that of seizure control and number of medications taken by the patient were related with a p value of <0.001, <0.001, 0.017 respectively.  Multiple regression of the combined effects of quality of life, medication adherence, and number of medication as explanatory variables on seizure control gave coefficient (R), adjusted Rand standard error of estimate as 0.979,  0.956, 0.632 respectively while each of the variable has effect on reduction of seizure episodes as -0.076,  0. 925, 0.176 respectively.

Conclusion: Quality of life, medication adherence, and number of medications are related with seizure control; these variables have combined effect of more than nine-tenth on variability of seizure control while their individual effects are at least one-tenth on alteration of frequency of seizure episode.

 

 

Keywords: Seizure-control, quality-of-life, medication-Adherence, epilepsy

Journal Metrics
Impact Factors
» Thompson Reuters (ISI): 0.000 (2020)
» H-5 index: XX (2020)
» SCImago Journal Rank (SJR): 0.000


Manuscripts
» Submission to first review: 07-14 days
» Submission to acceptance: 20-30 days
» Acceptance to publication: 20-30 days

Article Tools

Share this article with



Archives

2020; 7: 
1.
2019; 6: 
1.
2018; 5: 
1, 2.
2017; 4: 
1.
2016; 3: 
1.
2015; 2: 
1.
2014; 1: 
1.