Abigail M Akhigbemen
,
Chidiebere O Oluwaseyi,
For correspondence:- Abigail Akhigbemen Email: abigail.omo-isibor@uniben.edu Tel: +2347032470846
Citation: Akhigbemen AM, Oluwaseyi CO, Anxiolytic and anti-depressant effects of Bombax buonopozense in streptozotocin-induced diabetic rats. J Sci Pract Pharm 2024; 11(1):543-548 doi:
© 2024 The author(s).
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Introduction: Diabetes Mellitus (DM) is a metabolic disorder resulting in the presence of chronic hyperglycemia. There seems to be a bi-directional association between diabetes, anxiety and depression. Purpose: This study evaluates the effect of Bombax buonopozense (BB) methanol stem- bark extract on stress, anxiety, depression in streptozotocin- induced diabetic rats Method: Oral acute toxicity was done with the Methanol stem bark extract of B. buonopozense using Lorke’s method Hyperglycemia was induced in rats by intraperitoneal injections of streptozotocin (STZ) at a dose of 45 mg/kg body weight. Hyperglycemic rats were subjected to behavioral test models such as forced swim test, elevated plus maze and sucrose splash test using test doses of 200, 400, and 800 mg/kg administered orally. Result: Oral acute toxicity studies recorded no mortality at doses up to 5000 mg/kg. There was no significant difference in the duration of immobility of rats on day 1, on day 7 there was a significant increase in the duration of mobility of rats that received 400 and 800mg/kg BB (*p<0.05, **p<0.01 respectively) There was a significant increase in the duration of time spent by the animals in open arm of the elevated plus maze by animals that received 200 mg/kg BB on day 1 ****p<0.0001 and animals that received doses of 400 and 800 mg/kg significantly (**p<0.01, ****p<0.0001 respectively) on day 7. In the sucrose splash test, there was no significant difference in duration of grooming amongst animals on day 1 but on day 7, there was a significant increase in the duration of grooming in animals that received 400 mg/kg BB when compared to diabetic untreated group. Conclusion: The extract of Bombax buonopozense is relatively safe; and possesses anti-depressant and anxiolytic-like properties.
